The Bagchi lab studies the characteristics and regulation of cell states in health and disease. We use human induced pluripotent stem cells (iPSCs), intact human and mouse tissues, pre-clinical rodent models and omics platforms to understand the molecular pathways that drive cellular plasticity in cardiovascular and metabolic diseases. We also employ genetic and pharmacological manipulations […]
Ellen van der Plas, Ph.D.
Tim Koscik, Ph.D.
Our research is focused on understanding the fine-scale neuroanatomy of the human brain, including cortical and cerebellar laminar architecture, in the context of neurodevelopment across the lifespan and in neurological disease. We conduct ultra-high-resolution neuroimaging of the postmortem brain, and we develop and deploy sophisticated analytical tools to push back the boundaries imposed by technological […]
Huiliang Zhang, Ph.D.
Andrew Morris, Ph.D.
KyoungHyun Kim, Ph.D.
Our laboratory focuses on the novel roles of the nuclear receptor NR2E3 in liver diseases and cancer. Of the 48 known human nuclear receptors, the biological functions of NR2E3 remain largely unexplored. Approximately 16% of FDA-approved drugs target nuclear receptors, including estrogen and androgen receptors, highlighting the translational potential of our NR2E3 research program. Our […]