The Bagchi lab studies the characteristics and regulation of cell states in health and disease. We use human induced pluripotent stem cells (iPSCs), intact human and mouse tissues, pre-clinical rodent models and omics platforms to understand the molecular pathways that drive cellular plasticity in cardiovascular and metabolic diseases. We also employ genetic and pharmacological manipulations in cells and mice to investigate how specific genes/proteins may cause cell state transitions, thereby contributing to cardiometabolic diseases.