My primary research interest is to understand how endocrine status, diet and environment contribute to urological diseases encompassing prostate cancer, benign prostatic hyperplasia and lower urinary tract dysfunctions, with a focus on the role of physiological / dietary / environmental estrogens in uropathology. The knowledge gained from our research will foster development of better strategies for the urologic disease prevention, management and treatment. Our ongoing projects also focus on the impact of early-life exposure to environmental stressors on later-life health outcomes (e.g., cancer risks and fertility), inter-/trans-generational epigenetic inheritance via epitranscriptomic mechanisms, and environmentally induced stem cell carcinogenesis.