The Delgado-Calle laboratory focuses on understanding the mechanisms by which cancer cells alter the biology of other cells in the tumor/bone marrow microenvironment, in particular osteocytes, with the final goal of identifying targetable factors for the treatment of cancer that grows in bone. We employ ex vivo and in vitro models to study osteocyte-tumor biology, and animal models of cancer-induced bone disease to characterize the effects of genetic and pharmacologic approaches on tumor growth and bone remodeling. Current projects in the laboratory investigate the effects osteocyte-derived factors and bidirectional Notch signaling between myeloma cells and osteocytes on MM progression, myeloma cell dormancy, and cancer-induced bone disease.