2014 – 2015 Publications | UAMS Graduate School

Biochemistry and Molecular Biology

Alford, S., Kothari, A ., Loeff, F., Eichhorn, J., Sakurikar, N., Goselink, H., Saylors, R.L.; Jedema, I., Falkenburg, J.H., Chambers, T.C. BH3 inhibitor sensitivity and bcl-2 dependence in primary acute lymphoblastic leukemia cells. Cancer Res. 2015 Feb 3. [Epub ahead of print].

Eichhorn, J., Kothari, A ., & Chambers, T. Cyclin B1 overexpression induces cell death independent of mitotic arrest. PLoSOne. 2014 Nov 21;9(11):e113283. eCollection2014.

Li, Y., Hadden, C., Singh, P., Mercado, C., Murphy, P., Dajani, N., Lowery, C.L ., Roberts, D.J., Maroteaux, L., Kilic, F. GDM-associated insulin deficiency hinders the disassociation of SERT from ERp44 and down-regulates placental 5-HT uptake. ProcNatlAcadSciUSA. 2014 Dec 30;111(52): E5697-705.

Li, Y., Hadden, C., Singh, P., Mercado, C., Murphy, P., Dajani, N., Lowery, C.L ., Roberts, D.J., Maroteaux, L., Kilic, F. Insulin promotes serotonin uptake. SciSignal. 8, ec1 (2015).

Li, Y., & Kilic, F. The molecular link between SERT and ERp44 in gestational diabetes mellitus-associated pregnancy.. ASCB Annual Meeting. 2014 Dec 6-10;E72:116.

Maddukuri, L., Ketkar, A., Eddy, S ., Zafar, M. K., Eoff, R. L. The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa. Nucleic Acids Res. 2014 Oct 29; 42(19):12027-40. Epub 2014 Oct 7.

Waldrip, ZJ , Byrum, SD, Storey, AJ, Gao, J, Byrd, AK, Mackintosh, SG, Wahls, WP, Taverna, SD, Raney, KD Tackett, AJ. A CRISPR-based approach for proteomic analysis of a single genomic locus. Epigenetics. 2014 Sep; 9(9):1207-11. Epub 2014 Jul 18.

Zafar, M. K ., Ketkar, A., Lodeiro, M. F., Cameroon, C. E., Eoff, R. L. Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2′-deoxyguanosine. Biochemistry 2014 Oct 21;53(41):6584-94. Epub 2014 Oct 10.

Ziu E, Hadden C, Li Y , Lowery CL , Singh P, Ucer SS , Mercado CP, Gu HH, Kilic F. Effect of serotonin on platelet function in cocaine exposed blood. SciRep. 2014 Aug 5;4:5945.

Bioinformatics

Ayyadevara, S.*, Balasubramaniam, M .*, Gao, Y., Li-Rong, Yu., Alla, R., Reis, R. (2014) Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes. Aging Cell. 2015 Feb; 14(1); 35-48. Epub 2014 Dec 16.

Jaiswal , M., Crabtree, N., Bauer, M., Hall, R., Raney, K., & Zybailov, B. XLPM: Efficient algorithm for the analysis of protein-protein contacts using chemical cross-linking mass spectrometry. BMC Bioinformatics, 2014; 15 Suppl11:S16. Epub 2014 Oct 21.

Cellular Physiology and Molecular Biophysics

Al-Dwairi, A., Brown, A. R ., Pabona, J. M. P., Van, T., Hamdan, H., Mercado, C. P., Quick, C.M., Wight, P.A., Simmen, R.C., Simmen, F.A. (2014). Enhanced gastrointestinal expression of cytosolic malic enzyme (ME1) induces intestinal and liver lipogenic gene expression and intestinal cell proliferation in mice. PloS One.

Fowler, T. W ., Kamalakar , A., Akel, N. S., Kurten, R. C., Suva, L. J., & Gaddy, D. Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures. J Cell Sci. 2015 Feb 15; 128(4):683-94. Epub 2015 Jan 20.

Hamdan , H., Kockara, N., Jolly, L., Haun, S., & Wight, P. Control of human PLP1 expression through transcriptional regulatory elements and alternatively spliced exons in intron 1. ASN Neuro. 2015 Feb 18; 7(1). Print 2015 Jan-Feb.

Heard, M.E., Simmons, C. D., Simmen, F.A., Simmen, R.C. Krϋppel-like factor 9 deficiency in uterine endometrial cells promotes ectopic lesion establishment associated with active notch and hedgehog signaling in a mouse model of endometriosis. Endocrinology. 2014 Apr; 155(4):1532-46. Epub 2014 Jan29.

Simmen, R.C., Heard, M ., Simmen, A., Montales, M.T., Marji, M., Scanlon, S., Pabona, J.M. The Krϋppel-like factors in female reproductive system pathologies. J MolEndocrinol. 2015 Apr; 54 (2): R89-R101. Epub 2015 Feb 5.

Health Systems and Services Research

Ali, M. M ., O’Brien, C. E., Cleves, M. A., & Martin, B. C. Exploring the possible association between montelukast and neuropsychiatric events among children with asthma: A matched nested case-control study. . Pharmacoepidemiol Drug Saf. 2015 Feb 12. [Epub ahead of print].

Interdisciplinary Biomedical Sciences

Bartell, S., Kim, H., Ambrogini, E., Han, L., Iyer, S., Ucer, S.S., Rabinovitch, P., Jilka, R.L., Weinstein, R.S., Zhao, H., O’Brien, C.A., Manolagas, S.C., Almeida, M. FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun. 2014 April 30;5:3773

Beenken, K. E., Mrak, L. N ., Zielinska, A. K., Atwood, D. N ., Loughran, A. J., Griffin, L. M., Matthews, K.A., Anthony, A.M., Spencer, H.J., Post, G.R., Lee, C.Y., Smeltzer, M.S. Impact of the functional status of saeRS on in vivo phenotypes of staphylococcus aureus sarAmutants. MolMicrobiol. 2014 Jun; 92(6):1299-312. Epub 2014 May 12.

Cecil, K., Mulkey, S ., Ou, X., & Glasier, C. (2015). Brain ketones detected by protocol MRS in infant with ohtahara syndrome treated with ketogenic diet. PediatrRadiol. 2015 Jan;45(1):133-7. Epub 2014 Jun 8.

Daniels, J., & Kadlubar, S. (2014). Pharmacogenetics of SULT1A1. Pharmacogenomics. 2014 Nov; 15(14): 1823-1838.

Faramawi, M. F., Delongchamp, R., Lin, Y. S., Liu, Y., Abouelenein, S., Fischbach, L., Jadhav, S. Environmental lead exposure is associated with visit-to-visit systolic blood pressure variability in the US adults. Int Arch Occup Environ Health. 2015; 88; 381-388.

FaramawiM.F., Delongchamp, R., Said, Q., Jadhav, S., Abouelenein, S . Metabolic syndrome is associated with visit-to-visit systolic blood pressure variability in the US adults. HypertensRes. 2014 Sep; 37(9); 875-9. Epub 2014 May 8.

Faramawi, M. F., Fischbach, L., Delongchamp, R., Cardenas, V., Abouelenein, S., Chedjieu, I. P., Taha, N. Obesity is associated with visit-to-visit systolic blood pressure variability in the US adults. J Public Health (Oxf). 2014 Dec 15. [Epub ahead of print].

Gess, J., Fausett, J., Kearney-Ramos, T ., Kilts, C., James, G.A. Task-dependent recruitment of resting state networks reflects normative variance in cognition. Brain Behav. 2014 Sep:4(5):650-64. Epub 2014 Jul 9.

Ha, J., Pokrovskaya, I., Climer, L ., Shimamura, G., Kudlyk, T., Jeffrey, P., Lupashin, V.V., Hughson, F.M. Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex. ProcNatlAcadSciUSA. 2014 Nov;111(44), 15762-7. Epub 2014 Oct 20.

Holthoff, E.R ., Jeffus, S.K., Gehlot, A. Stone, R., Erickson, S.W., Kelly T., Quick, C.M., Post, S.R. Perineural Invasion is an Independent Pathologic Indicator of Recurrence in Vulvar Squamous Cell Carcinoma. Am J. SurgPathol. 2015 Mar 16. [Epub ahead of print].

Jang, D., Penthala, N., Aposgolov, E. O., Wang, X., Crooks, P., & Basnakian, A. G. Novel high throughput DNase I assay. J BiomolScreening. 2015 Feb; 20(2): 202-11. Epub 2014 Oct 17.

Jang, D ., Penthala, N., Apostolov, E. O., Wang, X., Crooks, P., & Basnakian, A. G. Novel cytoprotective inhibitors for endonuclease G. DNA Cell Biol. 2015 Feb:34(2):92-100. Epub 2014 Nov 17.

Kearney-Ramos, T ., Fausett, J., Gess, J., Reno, A., Peraza, J., Kilts, C., James, G.A. Merging clinical neuropsychology and functional neuroimaging to evaluate the construct validity and neural network engagement of the n-back task. J IntNeuropsycholSoc. 214 Aug;20(7): 736-50. Epub 2014 Jun 25.

Levy, J. W., Hartman, J. H ., Perry, M. D. J., & Miller, G. P. Structural basis for cooperative binding of azoles to CYP2E1 as interpreted through guided molecular dynamics simulations. J Mol Graph Model. 2015 Mar; 56:43-52. Epub 2014 Dec 6.

Li, Y., Hadden, C., Singh, P., Mercado, C., Murphy, P., Dajani, N., Lowery, C.L ., Roberts, D.J., Maroteaux, L., Kilic, F. Insulin promotes serotonin uptake. SciSignal. 8, ec1 (2015).

Loughran, A. J., Atwood, D. N ., Anthony, A. C., Harik, N. S., Spencer, H. J., Beenken, K. E., Smeltzer, M.S. (2014). Impact of individual extracellular proteases on staphylococcus qureus biofilm formation in diverse clinical isolates and their isogenic sarAmutants. Microbiologyopen. 2014 Dec; 3(6):897-909. Epub 2014 Sep 25.

Lyn-Cook, L., Word, B., George, N., Lyn-Cook, B., Hammons, G. Effect of cigarette smoke condensate on gene promoter methylation in human lung cells. TobInducDis. 2014 Sep 5;12(1):15. eCollection2014.

Marshell, R., Kearney-Ramos, T ., Brents, L., Hyatt, W., Tai, S., Prather, P., Fantegrossi, W.E. In vivo effects of synthetic cannabinoids JWH-018 and JWH-073 and phytocannabinoidΔ9-THC in mice: Inhalation versus intraperitoneal injection. PharmacolBiochemBehav. 2014 Sep; 142:40-7. Epub 2014 May 21.

Mulkey, S. B . Treatment advances in the neonatal intensive care unit with a neonatal neurologist” in treatment strategies ─ Paediatrics. The Cambridge Research Centre, ebook Dec 5 2014.

Mulkey, S ., Ou, X., Ramakrishnaiah, R., Glasier, C., Swearingen, C., Melguizo, M.,Yap, V.L., Schmitz, M.L., Bhutta, A.T. White matter injury in newborns with congenital heart disease-a diffusion tensor imaging study. PediatrNeurology. 2015 Sep;51(3):377-83. Epub 2014 Apr 12.

Pugh, C. P., Pouncey, D. L., Hartman, J. H., Nshimiyimana, R., Desrochers, L. P., Goodwin, T. E., Boysen, G., Miller, G.P. Multiple UDP-glucuronosyltransferases in human liver microsomesglucuronidate both R- and S-7-hydroxywarfarin into two metabolites. Arch BiochemBiophys. 2014 Dec 15; 564:244-53. Epub 2014 Oct 19.

Ucer, S., Iyer, S., Bartell, S., Martin-Millan, M., Han, L., Kim, H., Weinstein, R.S., Jilka, R.L., O’Brien, C.A., Almeida, M., Manolagas, S.C. The effects of androgens on murine cortical bone do not require AR or ERα signaling in osteoblasts and osteoclasts. J Bone Miner Res. 2015 Feb 19. [Epub ahead of print].

Yang, C.S., Mercer, K.E., Alund, A.W ., Suva, L.J., Badger, T.M., Ronis, M.J. (2014). Geinstein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice. ExpBiol Med; 239(10); 1380-9. Epub 2014 May 28.

Ziu E, Hadden C, Li Y , Lowery CL , Singh P, Ucer SS , Mercado CP, Gu HH, Kilic F. Effect of serotonin on platelet function in cocaine exposed blood. SciRep. 2014 Aug 5;4:5945.

Interdisciplinary Toxicology

Gannon, B.M., Reichard, E.E ., Fantegrossi, W.E. Psychostimulant Abuse and HIV Infection: cocaine, methamphetamine, and “bath salt” cathinone analogues. Current Addiction Reports. 2015;1(3): 237-4.

Nikolic, D.M., Vadali, S ., He, B., Ware, J., Kelly, T., Post, S.R. Prostaglandins Produced During Class A Scavenger Receptor-Mediated Macrophage Adhesion Differentially Regulate Cytokine Production. J LeukocBiol. 2015 Feb 25. [Epub ahead of print]

Ronis, M.J., Mercer, K.E., Gannon, B., Engi, B., Zimniak, P., Shearn, C.T., Orlicky, D.J., Albano, E., Badger, T.M., Peterson, D.R. Increased 4-hydroxynonenal protein adducts in males GSTA4-4/PPAR-α Double Knockout mice Enhance Injury During Early Stages of Alcoholic Liver Disease. Am J PhysiolGastrointest Liver Physiol. 2015 Mar 1;308(5):G403-15.

Vadali, S ., Post, S.R. Lipid rafts couple class A scavenger receptors to phospholipase A2 activation during macrophage adhesion. J LeukocBiol. 2014 Nov;96(5):873-81. Epub 2014 Jul 28.

Microbiology and Immunology

Fortune, D.E., Lin, Y.P., Deka, R.K., Groshong, AM., Moore, B.P., Hagman, K.J., Leong, J.M., Norgard, M.V., Tomchick, D.R., Blevins, J.S. Identification of Lysine Residues in the BorreliaburgdorferiDbpAAdhesin for Murine Infection. Infect Immun. 2014 Aug;82(8);3186-98. Epub 2014 May 19.

Graham, J.G ., Winchell, C.G., Sharma, U.M., Voth, D.E. (2015) Identification of ElpA, a CoxiellaburnettiPathotype-Specific Dot/Icm Type IV Secretion System Substrate. Infect Immun, 83(3), 1190-8.

Groshong, A.M., Fortune, D.E ., Moore, B.P., Spencer, H.J., Bellamy, W., Blevins, J.S. BB0238, a presumed tetratricopeptide repeat (TPR)-containing protein, is required during Borreliaburgdorferi mammalian infection. Infect Immun. 2014 Oct; 82(10), 4292-306. Epub 2014 Jul 28.

Winchell, C.G., Graham, J.G., Kurten, R.C., Voth, D.E. (2014). Coxiellaburnetii type IV secretion-dependent recruitment of macrophage autophages. Infect Immun. 82(6), 2229.

Neurobiology and Developmental Sciences

D’onofrio, S ., Kezunovic, N., Hyde, J., Luster, B., Messias, E., Urbano, F., Garcia-Rill, E. Modulation of gamma oscillations in the pedunculopontine nucleus (PPN) by neuronal calcium sensor protein-1 (NCS-1): Relevance to schizophrenia and bipolar disorder. J Neurophysiol. 2015 Feb 1;113(3):709-10. Epub 2014 Nov. 5.

Drew, P. D., Johnson, J. W., Douglas, J. C ., Phelan, K. D ., & Kane, C. J. Pioglitazone blocks ethanol induction of microglial activation and immune responses in the hippocampus, cerebellum, and cerebral cortex in a mouse model of fetal alcohol spectrum disorders. Alcohol ClinExpRes. 2015 Mar; 39(3):445-54. Epub 2015 Feb 19.

Garcia-Rill, E., Kezunovic, N., D’onofrio, S., Luster, B. , Hyde, J., Bisagno, V., Urbano, F.J. Gamma band activity in the RAS-intracellular mechanisms. Exp Brain Res. 2014 May; 232(5):1509-22. Epub 2013 Dec 6.

Urbano FJ, D’onofrio S , Luster B, Beck P, Hyde J, Bisagno V, Garcia-Rill E. Pedunculopontine nucleus gamma band activity – preconscious awareness, waking, and REM sleep. Front Neurol. 2014 Oct 20;5:2010. eCollection2014.

Nursing Sciences

Hays, L. Transition to adult congenital heart disease: A review. J PediatrNurs. 2015 Feb 19. [Epub ahead of print].

McSweeney, J., & Kitch, S. Commentary: “Impact of prodromal symptoms in future adverse cardiac-related events: A systematic review”. J CardiovascNurs. 2014 Nov 21. [Epub ahead of print].

Pharmaceutical Sciences

Shewale, A., Johnson, J., Li, C., Nelsen, D., & Martin, B. Variation in anticoagulant recommendations by the guidelines and decision tools among patients with atrial fibrillation. Healthcare. 2014;3(1):130-145.

Pharmacology

Sims, C. R., MacMillan-Crow, L. A., & Mayeux, P. R. Targeting mitochondrial oxidants may facilitate recovery of renal function during infant sepsis. ClinParmacolTher. 2014 Dec;29(6):662-4. Epub 2014 Aug 22.

Wang, Z., Sims, C. R., Patil, N. K., Gokden, N., & Mayeux, P. R. Pharmacologic targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse. J PharmacolExpTher. 2015 Jan;352(1):61-6. Epub 2014 Oct 29.