UAMS.EDU

2015-2016 Publications

Biochemistry & Molecular Biology

Eddy S, Maddukuri L, Ketkar A, Zafar MK, Henninger EE, Pursell ZF, et al. Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA. Biochemistry. 2015; 54:3218-30.

Gao J, Zybailov BL, Byrd AK, Griffin WC, Chib S, Mackintosh SG, et al. Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA. Chem Commun (Camb). 2015; 51:7242-7244.

Molden BM, Cooney KA, West K, Van Der Ploeg LH, Baldini G. Temporal cAMP signaling selectivity by natural and synthetic MC4R agonists. Mol Endocrinol. 2015; 29:1619-1633.

Protacio RU, Storey AJ, Davidson MK, Wahls WP. Nonsense codon suppression in fission yeast due to mutations of tRNA(Ser.11) and translation release factor Sup35 (eRF3). Curr Genet. 2015; 61:165-173.

Sengupta D, Byrum SD, Avaritt NL, Davis L, Shields B, Mahmoud F, et al. Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma. Mol Cell Proteomics. 2016; 15:765-775.

Sengupta D, Kannan A, Kern M, Moreno MA, Vural E, Stack BJ, et al. Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma. Epigenetics. 2015; 10:460-466.

Cellular Physiology & Molecular Biophysics

Bailey Blackburn J, Pokrovskaya I, Fisher P, Ungar D, Lupashin V. COG Complex complexities: Detailed characterization of a complete set of HEK293T cells lacking individual COG subunits. Front Cell Dev Biol. 2016; 4.

Heard ME, Velarde MC, Giudice LC, Simmen FA, Simmen RC. Krüppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis. Biol Reprod. 2015; 92:140, Epub Apr 22..

Jolly LA, Novitskiy S, Owens P, Massoll N, Cheng N, Fang W, et al. BrafV600E and Pten loss cooperate in thyroid cancer progression and the development of a fibrotic tumor stroma enriched with collagen. Cancer Res. 2016; Epub Jan 27.

Megyesi J, Tarcsafalvi A, Seng NSHL, Hodeify R, Price PM. Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak. Cell Death Discovery. 2016; 308:F122-F130.

Seng NS, Megyesi J, Tarcsafalvi A, Price PM. Mimicking Cdk2 phosphorylation of Bcl-xL at Ser73 results in caspase activation and Bcl-xL cleavage. Cell Death Discovery. 2016; Epub Feb 1.

Communication Sciences and Disorders

Atcherson SR, Childress T, Kennett SE. Hearing assistive and access technologies and applications to auditory-verbal therapy. Auditory-Verbal Therapy for Young Children with Hearing Loss and Their Families, and the Practitioners Who Guide Them. 2016.

Atcherson SR, Nagaraj N, Kennett SEW, Levisee M. Overview of central auditory processing deficits in older adults. Seminars in Hearing. 2015; 36:150-161.

Pharmaceutical Sciences

Brown JD, Hutchison LC, Li C, Painter JT, Martin BC. Predictive Validity of the Beers and Screening Tool of Older Persons Potentially Inappropriate Prescriptions (STOPP) Criteria to Detect Adverse Drug Events, Hospitalizations, and Emergency Department Visits in the United States. J Am Geriatr Soc. 2016; 64:22-30.

Hayes CJ, Hudson TJ, Phillips MM, Bursac Z, Williams JS, Austin MA, et al. The influence of propoxyphene withdrawal on opioid use in veterans. Pharmacoepidemiol Drug Saf. 2015; 24:1180-1188.

Patil PR, Wolfe J, Said Q, Thomas J, Martin BC. Opioid Use in the Management of Diabetic Peripheral Neuropathy (DPN) in a Large Commercially Insured Population. Clin J Pain. 2015; 31:414-424.

Shewale AR, Johnson JT, Li C, Nelsen D, Martin BC. Net Clinical Benefits of Guidelines and Decision Tool Recommendations for Oral Anticoagulant Use among Patients with Atrial Fibrillation. J Stroke Cerebrovasc Dis. 2015; 24:2845-2853.

Wan A, Penthala NR, Fifer EK, Parkin S, Crooks PA. Comparison of the crystal structures of 4, 4′-bis [3-(4-methylpiperidin-1-yl) prop-1-yn-1-yl]-1, 1′-biphenyl and 4, 4′-bis [3-(2, 2, 6, 6-tetramethylpiperidin-1-yl) prop-1-yn-1-yl]-1, 1′-biphenyl. Acta Crystallogr E Crystallogr Commun. 2015; 71:1132-1135.

Wan A, Penthala NR, Fifer EK, Parkin S, Crooks PA. Comparison crystal structure conformations of two structurally related biphenyl analogues: 4, 4′-bis [3-(pyrrolidin-1-yl) prop-1-yn-1-yl]-1, 1′-biphenyl and 4, 4′-bis {3-[(S)-2-methylpyrrolidin-1-yl] prop-1-yn-1-yl}-1, 1′-biphenyl. Acta Crystallogr E Crystallogr Commun. 2015; 71:1147-1150.

Interdisciplinary Biomedical Sciences

Atwood DN, Beenken KE, Lantz TL, Meeker DG, Lynn WB, Mills WB, et al. Regulatory mutations impacting antibiotic susceptibility in an established Staphylococcus aureus biofilm. Antimicrob Agents Chemother. 2016; 60:1826-1829.

Atwood DN, Beenken KE, Loughran AJ, Meeker DG, Lantz TL, Graham JW, et al. XerC contributes to Staphylococcus aureus biofilm-associated versus acute infections via agr-independent and agr-dependent pathways respectively. Infection and Immunity. 2016; Epub Feb 8.

Atwood DN, Loughran AJ, Courtney AP, Anthony AC, Meeker DG, Spencer HJ, et al. Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation. Microbiologyopen. 2015; 4:436-451.

Beck P, Garcia-Rill E. Development and the RAS. Waking and the Reticular Activating System in Health and Disease. 2015: 81-106.

Bostian AC, Maddukuri L, Reed MR, Savenka T, Hartman JH, Davis L, et al. Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells. Chem Res Toxicol. 2016; 29:101-108.

Brown AR, Simmen RCM, Raj VR, Van TT, MacLeod SL, Simmen FA. Krüppel like factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling. Carcinogenesis. 2015; 36:946-955.

Climer LK, Dobretsov M, Lupashin V. Defects in the COG complex and COG-related trafficking regulators affect neuronal Golgi function. Neurosci. 2015; 9:405.

Eddy S, Maddukuri L, Ketkar A, Zafar MK, Henninger EE, Pursell ZF, et al. Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA. Biochemistry. 2015; 54:3218-3320.

Hartman JH, Letzig LG, Roberts DW, James LP, Fifer EK, Miller GP. Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures. Biochem Pharmacol. 2016; 97:341-349.

Hartman JH, Martin HC, Caro AA, Pearce AR, Miller GP. Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates. Toxicology. 2015; 338:47-58.

Holthoff ER, Jeffus SK, Gehlot A, Stone R, Erickson SW, Kelly T, et al. Perineural Invasion Is an Independent Pathologic Indicator of Recurrence in Vulvar Squamous Cell Carcinoma. Am J Surg Pathol. 2015; 39:1070-1074.

Howell MD, Bailey LA, Cozart MA, Gannon BM, Gottschall PE. Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice. Acta Neuropathol Commun. 2015; 3:54.

Jeffus SK, Gehlot A, Holthoff E, Stone R, Spencer H, Kelly T, et al. A fibromyxoid stromal response is associated with an infiltrative tumor morphology, perineural invasion, and lymph node metastasis in squamous cell carcinoma of the vulva. Am J Surg Pathol. 2015; 39:1226-1233.

Koonce NA, Levy J, Hardee ME, Jamshidi-Parsian A, Vang KB, Sharma S, et al. Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia. PLoS One. 2015; 10(8).e0135607

Koonce NA, Quick CM, Hardee ME, Jamshidi-Parsian A, Dent JA, Paciotti GF, et al. Combination of Gold Nanoparticle-Conjugated Tumor Necrosis Factor-α and Radiation Therapy Results in a Synergistic Antitumor Response in Murine Carcinoma Models. Int J Radiat Oncol Biol Phys. 2015; 93:588-596.

Li Y, Cooper A, Odibo IN, Ahmed A, Murphy P, Koonce R, et al. Discrepancy in insulin regulation between GDM-platelets and -placenta. J Biol Chem. 2016; epub Feb 26.

Li Y, Hadden C, Cooper A, Ahmed A, Wu H, Lupashin VV, et al. Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability. Sci Rep. 2016; 6:22747.

Mazur A, Holthoff E, Vadali S, Kelly T, Post SR. Cleavage of Type I Collagen by Fibroblast Activation Protein-α Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion. PLoS One. 2016; 11(3):e150287.

Meeker DG, Jenkins SV, Miller EK, Beenken KE, Loughran AJ, Powless A, et al. Synergistic Photothermal and Antibiotic Killing of Biofilm-Associated Staphylococcus aureus Using Targeted Antibiotic-Loaded Gold Nanoconstructs. ACS Infect Dis. 2016; Epub Feb 10.

Megyesi J, Tarcsafalvi A, Seng NSHL, Hodeify R, Price PM. Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak. Cell Death Discovery. 2016; Epub Jan 18.

Molden BM, Cooney KA, West K, Van Der Ploeg LH, Baldini G. Temporal cAMP signaling selectivity by natural and synthetic MC4R agonists. Mol Endocrinol. 2015; 9:1619-1633.

Sengupta D, Byrum SD, Avaritt NL, Davis L, Shields B, Mahmoud F, et al. Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma. Mol Cell Proteomics. 2016; 15:765-775.

Wikenheiser DJ, Ghosh D, Kennedy B, Stumhofer JS. The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection. J Immunol. 2016;196:778-791.

Interdisciplinary Toxicology

Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, Gannon BM, Miller GW, Porter JH, Shoichet BK, Fantegrossi WE, Wetsel WC and Roth, BL. In vitro and in vivo characterization of the alkaloid nuciferine. PLoS ONE. 2016; 11(3):e150602.

Gannon BM, Williamson A, Rice KC and Fantegrossi WE. Stereoselective effects of abused “bath salt” constituent 3,4-methylenedioxypyrovalerone (MDPV) in mice: drug discrimination, locomotor activity, and thermoregulation. J Pharmacol Exp Ther. 2016; 356:615-623.

Gottschall PE, Howell MD. ADAMTS expression and function in central nervous system injury and disorders. Matrix Biol. 2015; 44:70-76.

Howell MD, Bailey LA, Cozart MA, Gannon BM, Gottschall PE. Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice. Acta Neuropathol Commun. 2015; 3:54.

Lieblong BJ, Sridharan V, Srivastava AK, Moros EG, Sharma SK, Boerma M. Role of the bradykinin B2 receptor in a rat model of local heart irradiation. Int J Radiat Biol. 2015; 91:634-642.

Mazur A, Holthoff E, Vadali S, Kelly T, Post SR. Cleavage of Type I Collagen by Fibroblast Activation Protein-α Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion. PLoS One. 2016; 11(3) e150287.

Microbiology & Immunology

Atwood DN, Beenken KE, Loughran AJ, Meeker DG, Lantz TL, Graham JW, et al. XerC contributes to Staphylococcus aureus biofilm-associated versus acute infections via agr-independent and agr-dependent pathways respectively. Infection and Immunity. 2016; Epub Feb 8.

Atwood DN, Loughran AJ, Courtney AP, Anthony AC, Meeker DG, Spencer HJ, et al. Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation. Microbiologyopen. 2015; 4:436-451.

Elliott MB, Litteken CD, Wang X. The Role of Breastfeeding in Moderating the Association between Gestational Diabetes Mellitus and Later Diabetes Mellitus. J Diabet Med Care. 2016; 1:1.

Meeker DG, Jenkins SV, Miller EK, Beenken KE, Loughran AJ, Powless A, et al. Synergistic Photothermal and Antibiotic Killing of Biofilm-Associated Staphylococcus aureus Using Targeted Antibiotic-Loaded Gold Nanoconstructs. ACS Infect Dis. 2016; Epub Feb 10.

Wikenheiser DJ, Ghosh D, Kennedy B, Stumhofer JS. The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection. J Immunol. 2016; 196:778-791.

Neurobiology & Developmental Sciences

Allensworth-James M, Odle AK, Haney A, Akhter N, Syed M, Childs GV. Sex Differences in Somatotrope Dependency on Leptin Receptors in Young Mice: Ablation of LEPR causes severe growth hormone deficiency and abdominal obesity in males. Endocrinology. 2015; 156:3253-3264.

D’Onofrio S, Messias E, Garcia-Rill E. Psychiatric disorders and the RAS. Waking and the Reticular Activating System in Health and Disease. 2015:227-254.

D’Onofrio S, Kezunovic N, Hyde JR, Luster B, Messias E, Urbano FJ, et al. Modulation of gamma oscillations in the pedunculopontine nucleus (PPN) by neuronal calcium sensor protein-1 (NCS-1): relevance to schizophrenia and bipolar disorder. J Neurophysiol. 2015; 113:709-719.

Garcia-Rill E, D’Onofrio S, Mahaffey S, Bisagno V, Urbano FJ. Pedunculopontine arousal system physiology- implications for schizophrenia. Sleep Sci. 2015; 8:82-91.

Garcia-Rill E, Luster B, D’Onofrio S, Mahaffey S, Bisagno V, Urbano FJ. Pedunculopontine arousal system physiology- deep brain stimulation (DBS). Sleep Sci. 2015; 8:153-161.

Garcia-Rill E, Luster B, Mahaffey S, Bisagno V, Urbano FJ. Pedunculopontine arousal system physiology- implications for insomnia. Sleep Sci. 205; 8:92-99.

Garcia-Rill E, Luster B, Mahaffey S, MacNicol M, Hyde JR, D’Onofrio S, et al. Pedunculopontine gamma band activity and development. Brain Sci. 2015; 5:546-567.

Garcia-Rill E, Simon C. The EEG and the discovery of the RAS. Waking and the Reticular Activating System in Health and Disease. 2015:17-34.

Hyde J, Garcia-Rill E. Ascending projections of the RAS. Waking and the Reticular Activating System in Health and Disease. 2015:107-28.

Kezunovic N, Hyde J, Urbano FJ, Garcia-Rill E. Gamma band activity. Waking and the Reticular Activating System in Health and Disease. 2015:171-208.

Luster B, D’Onofrio S, Urbano F, Garcia-Rill E. High-Threshold Ca2+ channels behind gamma band activity in the

pedunculopontine nucleus (PPN). Physiol Rep. 2015; 3(6):e12431.

Luster B, Petersen E, Garcia-Rill E. Neurological disorders and the RAS. Waking and the Reticular Activating System in Health and Disease. 2015:255-76.

Odle AK, Allensworth-James M, Haney A, Akhter N, Syed M, Childs GV. Adipocyte versus Somatotrope Leptin:  Regulation of Metabolic Functions in the Mouse. Endocrinology. 2016; Epub Feb 9.

Odle AK, Drew P, Childs GV. Giant Mice Reveal New Roles for GH In Regulating The Adipose Immune Microenvironment. Endocrinology. 2015; 156:1613-1615.

Urbano FJ, Bisagno V, Gonzalez B, Rivero-Echeto MC, Muniz JA, Luster B, et al. Pedunculopontine arousal system physiology- effects of psychostimulant abuse. Sleep Sci. 2015; 8:162-168.

Yates C, Garcia-Rill E. Descending projections of the RAS. Waking and the Reticular Activating System in Health and Disease. 2015:129-56.

Nursing Science

Lefler LL, Hadley M, Tackett J, Thomason AP. New Cardiovascular Guidelines: Clinical Practice Evidence for the Nurse Practitioner. J Am Assoc Nurse Pract. 2015; Epub May 26.

Tate LM. Temporal discounting rates and their relation to exercise behavior in older adults. Physiol Behav. 2015; 152:295-199.

Thomason A, Capps N, Lefler L, Richard-Davis G. Factors Affecting Gynecologic and Sexual Assessment in Older Women: A Lesson for Primary Care Providers. Healthcare. 2015; 3:683-694.

Pharmacology

Howell MD, Bailey LA, Cozart MA, Gannon BM, Gottschall PE. Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice. Acta Neuropathol Commun. 2015; 3:54.

Lieblong BJ, Sridharan V, Srivastava AK, Moros EG, Sharma SK, Boerma M. Role of the bradykinin B2 receptor in a rat model of local heart irradiation. Int J Radiat Biol. 2015; 91:634-642.

Sims CR, Nguyen TC, Mayeux PR. Could Biomarkers Direct Therapy for the Septic Patient ? . J Pharmacol Exp Ther. 2016: Epub.

Stolarz AJ, Farris RA, Wiley CA, O’Brien CE, Price ET. Fenofibrate attenuates neutrophilic inflammation in airway epithelia: Potential repurposing for cystic fibrosis. Clin Transl Sci. 2015; 8:686-701.

Stolarz AJ, Rusch NJ. Gender Differences in Cardiovascular Drugs. Cardiovasc Drugs Ther. 2015; 29:403-410.