Cell Biology Track
Track Leader-Brian Storrie, Ph.D.
Giulia Baldini, Ph.D. (Biochemistry and Molecular Biology) Web profile
Molecular mechanism of storage and secretion of hormones in endocrine cells; Novel therapeutics for diabetes and obesity
Helen Benes, Ph.D. (Neurobiology and Developmental Sciences) Web profile
Insect models (fruitflies, mosquitoes) to study molecular basis for regulated gene activity, in response to gender, nutrition, aging and oxidative stress, for insight into human reproductive development, diseases of aging, including cardiac ischemia.
Puran Bora, Ph.D. (Opthalmology) Web profile
Age Related Macular Degeneration (AMD), an eye disease which can cause loss of central vision in the population over the age of 50. Our laboratory is studying the Molecular and Biochemical mechanisms of AMD and uvietis in order to find a cure and/or prevention of the diseases.
Dana Gaddy, Ph.D. (Physiology and Biophysics) Web profile
Our laboratory focuses on the endocrine, cellular and molecular mechanisms that govern the maintenance of the musculoskeletal system, with particular focus on the normal and pathophysiological changes associated with age, disuse, menopause, and metastatic disease.
Robert L. Jilka, Ph.D. (Internal Medicine)
Osteoblast apoptosis as a determinant of bone mass; the regulation of bone remodeling and osteoblast number by parathyroid hormone; the impact of lipid oxidation on osteoblast differentiation and its role in age-related bone loss.
Thomas Kelly, Ph.D. (Pathology)
Proteases and heparanases in cancer metastasis
Lee Ann MacMillan-Crow, Ph.D. (Pharmacology and Toxicology) Web profile
Our laboratory has been investigating the role that increased mitochondrial oxidant production has on the early events leading to renal dysfunction following renal preservation and warm ischemia/reperfusion (I/R) in vivo. Previous studies have suggested that inactivation of the major antioxidant within the mitochondria, manganese superoxide dismutase (MnSOD), plays a pivotal role in inducing renal injury during I/R injury. Using both cell and rodent models we are also assessing the therapeutic potential of known and novel antioxidants to alter I/R and transplantation induced renal dysfunction.
Philip Mayeux, Ph.D. (Pharmacology and Toxicology) Web profile
Renal epithelial cell signaling: My laboratory is studying signal transduction pathways in renal epithelial cells that result in oxidative stress (reactive oxygen and reactive nitrogen species) in response to bacterial toxins and peptide hormones.
Judit Megyesi, M.D. (Medicine)
Donald Mock, M.D., Ph.D. (Biochemistry and Molecular Biology) Web profile
Our research group uses biochemistry, molecular biology, physical chemistry, and organic chemistry to answer questions concerning the pathogenesis of vitamin-related birth defects and anemia of low birth weight infants.
Roy Morello, Ph.D. (Physiology and Biophysics and Genetics) Web profile
In my laboratory we study the function of novel genes, in particular those involved in bone formation, development, homeostasis and disease. We utilize the power of mouse gene targeting and conditional gene-inactivation techniques to generate ubiquitous or tissue-specific mutations in the mouse. With the use of cell biology, biochemistry, cell microscopy and genetic approaches we characterize the phenotype of these mice to understand the underlying gene function. The objective is to learn from the animal model and make correlations with relevant aspects of human disease and hence gain mechanistic insights of biological function.
Steve Post, Ph.D. (Pathology)
Our lab studies the coupling of specific receptors and signaling pathways to cell function and disease. Of particular interest are the regulation of macrophage scavenger receptors and their role in chronic inflammation. Another area of interest relates to understanding the signaling pathways that regulate cardiac myocyte survival.
Paul L. Prather, Ph.D.(Pharmacology and Toxicology) Web profile
Opioid and cannabinoid receptor signaling mechanisms; cell biology and therapeutic drug development for neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS)
Peter M. Price, Ph.D. (Internal Medicine)
Role of cell-cycle events in renal failure and cellular stress
Robert J. S. Reis, D. Phil (Geriatrics) Web profile
Nematode and cell-culture models of human neurodegenerative diseases, other age-associated diseases, and aging in general. Additional work with mouse and human tissue samples to relate these models to mammals, and with cancer cell lines to study the role of homologous recombination in tumor initiation and progression firstname.lastname@example.org
Rosalia C.M. Simmen, Ph.D. (Physiology and Biophysics) Web profile
Regulators of gene expression in the mammary gland and uterus that are essential for proper function and development
Brian Storrie, Ph.D. (Physiology and Biophysics) Web profile
Research focuses on two aspects of the secretory pathway in mammalian cells: 1)assembly and dynamics of the Golgi apparatus using cultured HeLa cells as the model and 2)assembly and function of alpha granules in human and mouse platelets.
Alan Tackett, Ph.D. (Biochemistry and Molecular Biology) Web profile
Our laboratory uses cutting-edge proteomic and biochemical tools to understand how chromatin-associated protein complexes regulate chromosome structure and thereby influence cellular mechanisms like gene transcription.
Wayne Wahls, Ph.D. (Biochemistry and Molecular Biology) Web profile
Chromosome dynamics; meiosis; homologous recombination; chromatin; combinatorial bZIP dimers and cellular growth control; stress-activated signal transduction pathways.
Fang Zheng, Ph.D. (Pharmacology, Interdisciplinary Toxicology) Web profile
Molecular and cellular mechanisms of neurotoxicity related to neurological disorders, using a multidisciplinary approach.