Aging Biology Track
Track Leader-Steven Barger, Ph.D.
Helen Benes, Ph.D. (Neurobiology and Developmental Sciences) Web profile
Insect models (fruitflies, mosquitoes) to study molecular basis for regulated gene activity, in response to gender, nutrition, aging and oxidative stress, for insight into human reproductive development, diseases of aging, including cardiac ischemia.
Puran Bora, Ph.D. (Opthalmology) Web profile
Age Related Macular Degeneration (AMD), an eye disease which can cause loss of central vision in the population over the age of 50. Our laboratory is studying the Molecular and Biochemical mechanisms of AMD and uvietis in order to find a cure and/or prevention of the diseases.
Marsha Eigenbrodt, M.D., M.P.H. (Cardiology)
As a pathologist and epidemiologist, I have broad interests in chronic diseases with a particular interest in the methodological issues facing observational and clinical studies. Specific interests include indicators of arteriosclerosis severity and vascular aging, gene-environmental interactions, orthostatic hypotension, stroke, the relationship between alcohol and cardiovascular disease, and novel vascular risk factors in renal disease.
Dana Gaddy, Ph.D. (Physiology and Biophysics) Web profile
Our laboratory focuses on the endocrine, cellular and molecular mechanisms that govern the maintenance of the musculoskeletal system, with particular focus on the normal and pathophysiological changes associated with age, disuse, menopause, and metastatic disease.
Sue Griffin, Ph.D. (Geriatrics)
Our interest centers on the influence of neuroinflammatory cytokines, in particular interleukin-1, in the genesis and progression of neurodegenerative diseases such Alzheimer’s disease, Down’s syndrome, AIDS, and Parkinson’s disease.
Robert L. Jilka, Ph.D. (Internal Medicine)
Osteoblast apoptosis as a determinant of bone mass; the regulation of bone remodeling and osteoblast number by parathyroid hormone; the impact of lipid oxidation on osteoblast differentiation and its role in age-related bone loss.
Joan McEwen, Ph.D. (Microbiology and Immunology)
Roy Morello, Ph.D. (Physiology and Biophysics and Genetics) Web profile
In my laboratory we study the function of novel genes, in particular those involved in bone formation, development, homeostasis and disease. We utilize the power of mouse gene targeting and conditional gene-inactivation techniques to generate ubiquitous or tissue-specific mutations in the mouse. With the use of cell biology, biochemistry, cell microscopy and genetic approaches we characterize the phenotype of these mice to understand the underlying gene function. The objective is to learn from the animal model and make correlations with relevant aspects of human disease and hence gain mechanistic insights of biological function.
Charles O’Brien,Ph.D. (Endocrinology)
Cellular and molecular mechanisms responsible for osteoporosis.
Jeanne Wei, M.D., Ph.D.(Geriatrics) Web profile
My research interests include the effect of age on cardiovascular homeostasis, transcription regulation and cardiac function. Current projects include both clinical and laboratory studies
Robert R. Wolfe, Ph.D. (Geriatrics)
Regulation of muscle metabolism, particularly as affected by aging and stressors such as injury, sepsis and cancer.
Xiaomin Zhang, M.D., Ph.D. (Geriatrics)
Our primary interest is transcriptional regulation of gene expression in senescence, especially the role of serum response factor (SRF) and SRF cofactors in the regulation of cardiac genes in the process of adult aging.