UAMS.EDU

Aging Biology Track

Track Leader-Steven Barger, Ph.D.

Steven Barger, Ph.D. (Geriatrics) Web profile
Cell biology of Alzheimer’s disease; transcriptional regulation in neurons
bargerstevenw@uams.edu

Helen Benes, Ph.D. (Neurobiology and Developmental Sciences) Web profile
Insect models (fruitflies, mosquitoes) to study molecular basis for regulated gene activity, in response to gender, nutrition, aging and oxidative stress, for insight into human reproductive development, diseases of aging, including cardiac ischemia.
beneshelen@uams.edu

Puran Bora, Ph.D. (Opthalmology) Web profile
Age Related Macular Degeneration (AMD), an eye disease which can cause loss of central vision in the population over the age of 50. Our laboratory is studying the Molecular and Biochemical mechanisms of AMD and uvietis in order to find a cure and/or prevention of the diseases.
pbora@uams.edu

Yuzhi Chen, Ph.D. (Geriatrics)Web profile
Protein degradation and signaling in Alzheimer’s disease; stem cell development in neurodegeneration and cancer
ChenYuzhi@uams.edu

Marsha Eigenbrodt, M.D., M.P.H. (Cardiology) 
As a pathologist and epidemiologist, I have broad interests in chronic diseases with a particular interest in the methodological issues facing observational and clinical studies. Specific interests include indicators of arteriosclerosis severity and vascular aging, gene-environmental interactions, orthostatic hypotension, stroke, the relationship between alcohol and cardiovascular disease, and novel vascular risk factors in renal disease.
eigenbrodtmarshal@uams.edu

Dana Gaddy, Ph.D. (Physiology and Biophysics) Web profile 
Our laboratory focuses on the endocrine, cellular and molecular mechanisms that govern the maintenance of the musculoskeletal system, with particular focus on the normal and pathophysiological changes associated with age, disuse, menopause, and metastatic disease.
gaddydana@uams.edu

Sue Griffin, Ph.D. (Geriatrics)
Our interest centers on the influence of neuroinflammatory cytokines, in particular interleukin-1, in the genesis and progression of neurodegenerative diseases such Alzheimer’s disease, Down’s syndrome, AIDS, and Parkinson’s disease.
GriffinSueT@uams.edu

Masahiro Higuchi, Ph.D. (Biochemistry and Molecular Biology) Web profile 
Roles of mitochondria and mitochondrial DNA on cancer progression and aging
Mhiguchi@uams.edu

Robert L. Jilka, Ph.D. (Internal Medicine)
Osteoblast apoptosis as a determinant of bone mass; the regulation of bone remodeling and osteoblast number by parathyroid hormone; the impact of lipid oxidation on osteoblast differentiation and its role in age-related bone loss.
JilkaRobertL@uams.edu

Joan McEwen, Ph.D. (Microbiology and Immunology) 
mcewenjoane@uams.edu

Roy Morello, Ph.D. (Physiology and Biophysics and Genetics) Web profile
In my laboratory we study the function of novel genes, in particular those involved in bone formation, development, homeostasis and disease. We utilize the power of mouse gene targeting and conditional gene-inactivation techniques to generate ubiquitous or tissue-specific mutations in the mouse. With the use of cell biology, biochemistry, cell microscopy and genetic approaches we characterize the phenotype of these mice to understand the underlying gene function. The objective is to learn from the animal model and make correlations with relevant aspects of human disease and hence gain mechanistic insights of biological function.
rmorello@uams.edu

Charles O’Brien,Ph.D. (Endocrinology)
Cellular and molecular mechanisms responsible for osteoporosis.
caobrien@uams.edu

Robert J.S. Reis, D. Phil. (Geriatrics) Web profile 
Genetics of longevity; role of homologous recombination in oncogenesis and cancer progression.
rjsr@uams.edu

Larry Suva, Ph.D. (Physiology and Biophysics) Web profile
Research interests are broad, but primarily associated with understanding the skeletal consequences of disease.
suvalarryj@uams.edu

Jeanne Wei, M.D., Ph.D.(Geriatrics) Web profile
My research interests include the effect of age on cardiovascular homeostasis, transcription regulation and cardiac function. Current projects include both clinical and laboratory studies
WeiJeanne@uams.edu

Robert R. Wolfe, Ph.D. (Geriatrics)
Regulation of muscle metabolism, particularly as affected by aging and stressors such as injury, sepsis and cancer.
rwolfe2@uams.edu

Xiaomin Zhang, M.D., Ph.D. (Geriatrics)
Our primary interest is transcriptional regulation of gene expression in senescence, especially the role of serum response factor (SRF) and SRF cofactors in the regulation of cardiac genes in the process of adult aging.
ZhangXiaomin@uams.edu